The Fujifilm GFX100S looks extremely small in comparison to its medium format competitors, even the Hasselblad X1D makes it look small at times and it still has a 50MP sensor inside. The X1D is a little skinnier and a little shorter than the GFX100S, but it lacks IBIS and the 102MP sensor inside the GFX100 and GFX100S. Surprisingly Hasselblad and Fujifilm have a lot of matching lens options that can be compared so if you are interested in more comparisons checkout camerasizecomparison for more information. You can also see my GFX vs X1D glass showdown here.
The Fujifilm GFX100S is even small enough to compare to the new Sony A1 with a lens attached, but the Sony does squeeze out the win the majority of the time if system size is your top concern. I’m not sure how they will make the GFX much smaller in the future, but I look forward to a GFX100R camera in the future. If Fujifilm excludes IBIS from the R line it could release a camera even smaller than the Hasselblad X1D, but it will require good form to use.
As for the Leica S line and Pentax 645 they are still clinging to a dated DSLR style design that won’t get much smaller, but do offer other advantages. I am not a fan of the Pentax 645, but there is a place in my heart for the Leica S because I captured some of my favorite photos of my children while they were young playing since the Leica S2 has a decent AF system. At this point, I think the only company that Fujifilm has to worry about is Hasselblad in the medium format space, but Leica could surprise us especially if they price their cameras reasonably.
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Fujifilm GFX100S: B&H Photo / Amazon / Moment / Adorama
Fujifilm GFX100: B&H Photo / Amazon / Adorama
Fujifilm GFX50R: B&H Photo / Amazon / Adorama
Fujifilm GFX 50S: B&H Photo / Amazon / Adorama
Fujinon GF80mm f/1.7: B&H Photo / Amazon / Moment / Adorama
Fujifilm H Mount Adapter G: B&H Photo / Amazon / Adorama
Leica S3: B&H Photo / Amazon / Adorama
Hasselblad X1D II 50C: B&H Photo / Amazon / Adorama
Pentax 645Z B&H Photo / Amazon / Adorama
Sony A1: B&H Photo / Amazon / Moment / Adorama